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Article

Impact of genetic and non-genetic factors on hepatic CYP2C9 expression and activity in Hungarian subjects.

Scientific reports - 24 Aug 2021

Fekete Ferenc, Mangó Katalin, Déri Máté, Incze Evelyn, Minus Annamária, Monostory Katalin

Abstract excerpt

CYP2C9, one of the most abundant hepatic cytochrome P450 enzymes, is involved in metabolism of 15-20% of clinically important drugs (warfarin, sulfonylureas, phenytoin, non-steroid anti-inflammatory drugs). To avoid adverse events and/or impaired drug-response, CYP2C9 pharmacogenetic testing is recommended. The impact of CYP2C9 polymorphic alleles (CYP2C9*2, CYP2C9*3) and phenoconverting non-genetic factors on...

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Identifiers

PMID: 34429480
DOI: 10.1038/s41598-021-96590-3
PMCID: PMC8384867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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