Pan-cancer analysis of mutations in open chromatin regions and their possible association with cancer pathogenesis.

Abstract excerpt

BACKGROUND: Open chromatin is associated with gene transcription. Previous studies have shown that the density of mutations in open chromatin regions is lower than that in flanking regions because of the higher accessibility of DNA repair machinery. However, in several cancer types, open chromatin regions show an increased local density of mutations in activated regulatory regions. Although the mutation...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chromatin
• Share to Genome, Human
• Share to Mutation