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Article

Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer

25 Jan 2021

Abstract excerpt

PURPOSE: Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease characterized by an extensive fibroinflammatory stroma, which includes abundant cancer-associated fibroblast (CAF) populations. PDAC CAFs are heterogeneous, but the nature of this heterogeneity is incompletely understood. The Hedgehog pathway functions in PDAC in a paracrine manner, with ligands secreted by cancer cells signaling to stromal...

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PMID: 33495315
DOI: 10.1158/1078-0432.ccr-20-3715

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