Article

Eribulin normalizes pancreatic cancer-associated fibroblasts by simulating TGFβ inhibition

2022-02-27

Abstract excerpt

Less than 11% of pancreatic cancer patients survive 5-years post-diagnosis. The unique biology of pancreatic cancer includes a significant expansion of its desmoplastic tumor microenvironment, wherein cancer-associated fibroblasts (CAFs) and their self-produced extracellular matrix are key components. CAF functions are both tumor-supportive and tumor-suppressive, while normal fibroblastic cells are solely tumor-su...

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Identifiers and source

Literature Corpus work: 46aadafb-488e-5ff9-b5aa-38f9f95fffae
DOI: 10.1101/2022.02.25.482033

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