Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adipose-derived mesenchymal stem cells differentiate into heterogeneous cancer-associated fibroblasts in a stroma-rich xenograft model

25 Feb 2021

Abstract excerpt

Cancer-associated fibroblasts (CAFs) are the key components of the densely proliferated stroma in pancreatic ductal adenocarcinoma (PDAC) and contribute to tumor progression and drug resistance. CAFs comprise heterogeneous subpopulations playing unique and vital roles. However, the commonly used mouse models have not been able to fully reproduce the histological and functional characteristics of clinical human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Epigenetics and DNA Methylation
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33633222
DOI: 10.1038/s41598-021-84058-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adipose-derived mesenchymal stem cells differentiate into heterogeneous cancer-associated fibroblasts in a stroma-rich xenograft modelPMID 33633222Read ↗

Adipose‐derived mesenchymal stem cells differentiate into pancreatic cancer‐associated fibroblasts in vitroSemantic proximity Read ↗

Inter‐ and intra‐tumoural heterogeneity in cancer‐associated fibroblasts of human pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Fibroblast Heterogeneity in the Pancreatic Tumor MicroenvironmentSemantic proximity Read ↗

The Cellular Origins of Cancer-Associated Fibroblasts and Their Opposing Contributions to Pancreatic Cancer GrowthSemantic proximity Read ↗

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated FibroblastsSemantic proximity Read ↗

Elucidation of tumor-stromal heterogeneity and the ligand-receptor interactome by single cell transcriptomics in real-world pancreatic cancer biopsiesSemantic proximity Read ↗

Comparison of Different Approaches to Single Cell RNA Sequencing of Cancer Associated FibroblastsSemantic proximity Read ↗

Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture systemSemantic proximity Read ↗

Pancreatic Fibroblast Heterogeneity: From Development to CancerSemantic proximity Read ↗

Integrated cell atlas and tumoroids chart pancreatic cancer therapeutic targetsSemantic proximity Read ↗

Dynamic Evolution of Fibroblasts Revealed by Single-Cell RNA Sequencing of Human Pancreatic CancerSemantic proximity Read ↗

Cancer‐associated fibroblasts that restrain cancer progression: Hypotheses and perspectivesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.