Article
Interaction between cigarette smoking and genetic polymorphisms on the associations with age of natural menopause and reproductive lifespan: the Singapore Chinese Health Study.
Human reproduction (Oxford, England) - 30 May 2022
Huang Zhongwei, Chang Xuling, Wang Ling, Liu Jianjun, Heng Chew-Kiat, Khor Chiea-Chuen, Yuan Jian-Min, Koh Woon-Puay, Dorajoo Rajkumar
Abstract excerpt
STUDY QUESTION: Are there genetic variants that interact with smoking to reduce reproductive lifespan in East-Asian women? SUMMARY ANSWER: Our study corroborates several recently identified genetic loci associated with reproductive lifespan and highlights specific genetic predispositions that may interact with smoking status to adversely affect reproductive lifespan in East-Asian women. WHAT IS KNOWN ALREADY:...
Topics
- China
- Cigarette Smoking
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Longevity
- Menopause
- Polymorphism, Single Nucleotide
- Prospective Studies