Article
Genetic risk stratification and risk factors of early menopause in women: a multi-center study utilizing polygenic risk scores.
Frontiers in endocrinology - 1 Jan 2024
Zhong Wei, Wang Qihang, Peng Dingchuan, Zou Yangyun, Chen Yulin, Xia Yingying, Zhang Xin, Shu Mingming, Song Chunlan, Wang Yiran, Fu Yiyao, Wang Sishuo, Ma Yanmin, Bu Xiaomeng, Liang Yuexiu, Chen Yuzhen, Bai Wenpei, Chen Yanrong, Deng Chengyan, Zhang Wanyu, Zhou Ming, Lv Lijuan, Zhang Linyan, Lu Sijia, Shang Wei
Abstract excerpt
Objective: This study aims to evaluate the utility of polygenic risk scores (PRS) in women with early menopause (EM) and to investigate the clinical characteristics and risk factors associated with EM based on genetic risk. Study design: Genotyping data and clinical data from women with EM and women with normal age of menopause retrieved from UK Biobank were used for early menopause risk prediction model...
Topics
- Humans
- Female
- Risk Factors
- Middle Aged
- Menopause, Premature
- Multifactorial Inheritance
- Adult
- Risk Assessment
- Genetic Predisposition to Disease