Article
MicroRNA networks in FLT3-ITD acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America - 19 Apr 2022
Hoang Dinh Hoa, Zhao Dandan, Branciamore Sergio, Maestrini Davide, Rodriguez Ivan R, Kuo Ya-Huei, Rockne Russell, Khaled Samer K, Zhang Bin, Nguyen Le Xuan Truong, Marcucci Guido
Abstract excerpt
MiR-126 and miR-155 are key microRNAs (miRNAs) that regulate, respectively, hematopoietic cell quiescence and proliferation. Herein we showed that in acute myeloid leukemia (AML), the biogenesis of these two miRNAs is interconnected through a network of regulatory loops driven by the FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD). In fact, FLT3-ITD induces the expression of miR-155 through a...
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