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Article

MicroRNA-155 expression and function in AML: An evolving paradigm.

Experimental hematology - 1 Jun 2018

Narayan Nisha, Bracken Cameron P, Ekert Paul G

Abstract excerpt

Acute myeloid leukemia (AML) arises when immature myeloid blast cells acquire multiple, recurrent genetic and epigenetic changes that result in dysregulated proliferation. Acute leukemia is the most common form of pediatric cancer, with AML accounting for ~20% of all leukemias in children. The genomic aberrations that drive AML inhibit myeloid differentiation and activate signal transduction pathways that drive...

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PMID: 29601851
DOI: 10.1016/j.exphem.2018.03.007

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