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Article

NF-κB/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia.

Leukemia - 1 Mar 2015

Gerloff D, Grundler R, Wurm A A, Bräuer-Hartmann D, Katzerke C, Hartmann J-U, Madan V, Müller-Tidow C, Duyster J, Tenen D G, Niederwieser D, Behre G

Abstract excerpt

Almost 30% of all acute myeloid leukemias (AML) are associated with an internal tandem duplication (ITD) in the juxtamembrane domain of FMS-like tyrosine kinase 3 receptor (FLT3). Patients with FLT3-ITD mutations tend to have a poor prognosis. MicroRNAs (miRNAs) have a pivotal role in myeloid differentiation and leukemia. MiRNA-155 (MiR-155) was found to be upregulated in FLT3-ITD-associated AMLs. In this study,...

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Share to fms-Like Tyrosine Kinase 3
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

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Share to RNA, Small Interfering

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Source

Open in PubMed Open full text

Identifiers

PMID: 25092144
DOI: 10.1038/leu.2014.231
PMCID: PMC4490787

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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