Article
miR-155 promotes FLT3-ITD-induced myeloproliferative disease through inhibition of the interferon response.
Blood - 8 Jun 2017
Wallace Jared A, Kagele Dominique A, Eiring Anna M, Kim Carissa N, Hu Ruozhen, Runtsch Marah C, Alexander Margaret, Huffaker Thomas B, Lee Soh-Hyun, Patel Ami B, Mosbruger Timothy L, Voth Warren P, Rao Dinesh S, Miles Rodney R, Round June L, Deininger Michael W, O'Connell Ryan M
Abstract excerpt
FLT3-ITD+ acute myeloid leukemia (AML) accounts for ∼25% of all AML cases and is a subtype that carries a poor prognosis. microRNA-155 (miR-155) is specifically overexpressed in FLT3-ITD+ AML compared with FLT3 wild-type (FLT3-WT) AML and is critical for the growth of FLT3-ITD+ AML cells in vitro. However, miR-155's role in regulating FLT3-ITD-mediated disease in vivo remains unclear. In this study, we used a...
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