Article

Scalable assessment of genome editing off-targets associated with genetic variants

2024-07-25

Abstract excerpt

<h4>ABSTRACT</h4> Genome editing with RNA-guided DNA binding factors carries risk of off-target editing at homologous sequences. Genetic variants may introduce sequence changes that increase homology to a genome editing target, thereby increasing risk of off-target editing. Conventional methods to verify candidate off-targets rely on access to cells with genomic DNA carrying these sequences. However, for candidat...

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Literature Corpus work: 83ed1d57-d876-5829-815b-9593d28c2905
DOI: 10.1101/2024.07.24.605019

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