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Article

SOAT1: A Suitable Target for Therapy in High-Grade Astrocytic Glioma?

International journal of molecular sciences - 28 Mar 2022

Löhr Mario, Härtig Wolfgang, Schulze Almut, Kroiß Matthias, Sbiera Silviu, Lapa Constantin, Mages Bianca, Strobel Sabrina, Hundt Jennifer Elisabeth, Bohnert Simone, Kircher Stefan, Janaki-Raman Sudha, Monoranu Camelia-Maria

Abstract excerpt

Targeting molecular alterations as an effective treatment for isocitrate dehydrogenase-wildtype glioblastoma (GBM) patients has not yet been established. Sterol-O-Acyl Transferase 1 (SOAT1), a key enzyme in the conversion of endoplasmic reticulum cholesterol to esters for storage in lipid droplets (LD), serves as a target for the orphan drug mitotane to treat adrenocortical carcinoma. Inhibition of SOAT1 also...

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Adrenal Cortex Neoplasms
Adrenocortical Carcinoma
Brain Neoplasms
Glioblastoma
Glioma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isocitrate Dehydrogenase

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PMID: 35409086
DOI: 10.3390/ijms23073726
PMCID: PMC8998855

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