Article

Genetic Trajectory and Clonal Evolution of Multiple Primary Lung Cancer with Lymph Node Metastasis

2022-07-15

Abstract excerpt

<title>Abstract</title> <p>Multiple primary lung cancer (MPLC) with lymph node metastasis (LNM) is a rare phenomenon of multifocal lung cancer. The genomic landscapes of MPLC and the clonal evolution pattern between primary lung lesions and lymph node metastasis haven’t been fully illustrated. We performed whole-exome sequencing (WES) on 52 FFPE (Formalin-fixed Paraffin-Embedded) samples from 11 patients diagnose...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 90ccd919-78b4-5d34-b2b3-69f7b9e11ef8
DOI: 10.21203/rs.3.rs-1778376/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic Trajectory and Clonal Evolution of Multiple Primary Lung Cancer with Lymph Node MetastasisDOI 10.21203/rs.3.rs-1778376/v1Read

Genomic characteristics and immune landscape of super multiple primary lung cancer.Semantic proximity Read

Distinct gene mutation profiles among multiple and single primary lung adenocarcinomaSemantic proximity Read

Using molecular characteristics to distinguish multiple primary lung cancers and intrapulmonary metastases.Semantic proximity Read

Evolutionary Characteristics and Immunologic Divergence of Lung and Brain Metastasis Lesions in NSCLC.Semantic proximity Read

Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stagesSemantic proximity Read

Molecular Profiling reveals Tumor Immune Microenvironment Heterogeneity of Concurrent Lung Adenocarcinoma and Squamous Cell Carcinoma in Multiple Primary Lung CancersSemantic proximity Read

Timing and Origins of Local and Distant Metastases in Lung Cancer.Semantic proximity Read

Genomic comparison between cerebrospinal fluid and primary tumor revealed the genetic events associated with brain metastasis in lung adenocarcinoma.Semantic proximity Read

Optimizing the NGS-based discrimination of multiple lung cancers from the perspective of evolutionSemantic proximity Read

Genomic Alteration During Metastasis of Lung Adenocarcinoma.Semantic proximity Read

[Clonal relationship analysis of 4 cases of multifocal primary lung cancer diagnosed histologically based on next-generation sequencing].Semantic proximity Read

Whole-Exome Sequencing Identifies Somatic Mutations Associated With Lung Cancer Metastasis to the BrainSemantic proximity Read