Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer.

doi:10.1038/s41467-018-05327-w

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Article

Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer.

Nature communications - 6 Aug 2018

Nong Jingying, Gong Yuhua, Guan Yanfang, Yi Xin, Yi Yuting, Chang Lianpeng, Yang Ling, Lv Jialin, Guo Zhirong, Jia Hongyan, Chu Yuxing, Liu Tao, Chen Ming, Byers Lauren, Roarty Emily, Lam Vincent K, Papadimitrakopoulou Vassiliki A, Wistuba Ignacio, Heymach John V, Glisson Bonnie, Liao Zhongxing, Lee J Jack, Futreal P Andrew, Zhang Shucai, Xia Xuefeng, Zhang Jianjun, Wang Jinghui

Abstract excerpt

Subclonal architecture and genomic evolution of small-cell lung cancer (SCLC) under treatment has not been well studied primarily due to lack of tumor specimens, particularly longitudinal samples acquired during treatment. SCLC is characterized by early hematogenous spread, which makes circulating cell-free tumor DNA (ctDNA) sequencing a promising modality for genomic profiling. Here, we perform targeted deep...

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PMID: 30082701
DOI: 10.1038/s41467-018-05327-w
PMCID: PMC6079068

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