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Article

The genomic dynamics during progression of lung adenocarcinomas.

Journal of human genetics - 1 Aug 2017

Yang Bin, Luo Longhai, Luo Wen, Zhou Yong, Yang Chao, Xiong Teng, Li Xiangchun, Meng Xuan, Li Lin, Zhang Xiaopin, Wang Zhe, Wang Zhixin

Abstract excerpt

Intra-tumor heterogeneity is a big barrier to precision medicine. To explore the underlying clonal diversity in lung adenocarcinomas, we selected nine individuals with whole-genome sequencing data from primary and matched metastatic tumors as a cohort for study. Similar global pattern of arm-level copy number changes and large variations of somatic single-nucleotide variant between the primary and metastasis are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28381877
DOI: 10.1038/jhg.2017.40
PMCID: PMC5537414

Genes

CCNY
CDK4
CDKN3
FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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