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Evolution of small cell lung cancer tumor mutation: from molecular mechanisms to novel viewpoints.

Seminars in cancer biology - 1 Nov 2022

Guan Xiaojiao, Bao Guangyao, Liang Jie, Yao Yao, Xiang Yifan, Zhong Xinwen

Abstract excerpt

Small cell lung cancer (SCLC) is a clinically common malignant tumor originating from the lung neuroendocrine stem cells, which has a poor prognosis and accounts for approximately 15% of all lung cancer cases. However, research on its treatment has been slow, and the 5-year survival rate of patients with SCLC has been < 5% for many years. In recent years, the development and popularization of gene sequencing...

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PMID: 35367118
DOI: 10.1016/j.semcancer.2022.03.015

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