Article
Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cells.
Neoplasia (New York, N.Y.) - 1 Jun 2022
Haddock Sara, Alban Tyler J, Turcan Şevin, Husic Hana, Rosiek Eric, Ma Xiaoxiao, Wang Yuxiang, Bale Tejus, Desrichard Alexis, Makarov Vladimir, Monette Sebastien, Wu Wei, Gardner Rui, Manova Katia, Boire Adrienne, Chan Timothy A
Abstract excerpt
Mutations in IDH1 and IDH2 drive the development of gliomas. These genetic alterations promote tumor cell renewal, disrupt differentiation states, and induce stem-like properties. Understanding how this phenotypic reprogramming occurs remains an area of high interest in glioma research. Previously, we showed that IDH mutation results in the development of a CD24-positive cell population in gliomas. Here, we...
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