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IDH mutation and cancer stem cell.

Essays in biochemistry - 16 Sept 2022

Zhang Yang, Liu Yang, Lang Fengchao, Yang Chunzhang

Abstract excerpt

Cancer stem cells (CSCs) are a small population of cells in human malignancies that resemble the biology of human pluripotent stem cells. CSCs are closely related to the critical hallmarks in human cancers, ranging from oncogenesis to disease progression, therapeutic resistance, and overall outcome. Mutations in isocitrate dehydrogenase (IDH) were recently identified as founder mutations for human cancers. An...

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PMID: 35611837
DOI: 10.1042/EBC20220008

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