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Article

Clinical and molecular implications of RGS2 promoter genetic variation in severe asthma.

The Journal of allergy and clinical immunology - 1 Sept 2022

Cardet Juan Carlos, Kim Donghwa, Bleecker Eugene R, Casale Thomas B, Israel Elliot, Mauger David, Meyers Deborah A, Ampleford Elizabeth, Hawkins Gregory A, Tu Yaping, Liggett Stephen B, Ortega Victor E

Abstract excerpt

BACKGROUND: Regulator of G protein signaling (RGS) 2 terminates bronchoconstrictive Gαq signaling; murine RGS2 knockout demonstrate airway hyperresponsiveness. While RGS2 promoter variants rs2746071 and rs2746072 associate with a clinical mild asthma phenotype, their impact on human airway smooth muscle (HASM) contractility and asthma severity outcomes is unknown. OBJECTIVE: We sought to determine whether...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35398411
DOI: 10.1016/j.jaci.2022.03.024
PMCID: PMC9642856

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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