Article
Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene.
PLoS genetics - 1 Jul 2012
Himes Blanca E, Jiang Xiaofeng, Hu Ruoxi, Wu Ann C, Lasky-Su Jessica A, Klanderman Barbara J, Ziniti John, Senter-Sylvia Jody, Lima John J, Irvin Charles G, Peters Stephen P, Meyers Deborah A, Bleecker Eugene R, Kubo Michiaki, Tamari Mayumi, Nakamura Yusuke, Szefler Stanley J, Lemanske Robert F, Zeiger Robert S, Strunk Robert C, Martinez Fernando D, Hanrahan John P, Koppelman Gerard H, Postma Dirkje S, Nieuwenhuis Maartje A E, Vonk Judith M, Panettieri Reynold A, Markezich Amy, Israel Elliot, Carey Vincent J, Tantisira Kelan G, Litonjua Augusto A, Lu Quan, Weiss Scott T
Abstract excerpt
Bronchodilator response (BDR) is an important asthma phenotype that measures reversibility of airway obstruction by comparing lung function (i.e. FEV(1)) before and after the administration of a short-acting β(2)-agonist, the most common rescue medications used for the treatment of asthma. BDR also serves as a test of β(2)-agonist efficacy. BDR is a complex trait that is partly under genetic control. A...
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