Genetic deletion of the inflammatory bowel disease-associated risk gene Rgs14 aggravates experimental colitis.

Abstract excerpt

Regulators of G protein signaling (RGS) deactivate G proteins associated with G protein-coupled receptors (GPCRs), a large receptor family with diverse functions. Of the 20 RGS, the Rgs14 single-nucleotide polymorphism is associated with inflammatory bowel disease, and Rgs14 expression is higher in macrophages than in epithelial cells. This manuscript describes a novel conditional mouse line that enables deletion...

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