Article
Effect of the Arg16Gly β2-Adrenergic Receptor Polymorphism on Long-Term Mepolizumab Response and Clinical Remission in Severe Eosinophilic Asthma: A Genotype-Stratified, Multicenter Study.
Allergy - 1 Mar 2026
Nolasco Santi, Fagone Evelina, Campisi Raffaele, Portacci Andrea, Scioscia Giulia, Pelaia Corrado, Maglio Angelantonio, Candia Claudio, Quaranta Vitaliano Nicola, Carrieri Isabella, Saglia Alessandro, Vatrella Alessandro, Pelaia Girolamo, Vancheri Carlo, Foschino Barbaro Maria Pia, D'Amato Maria, Carpagnano Giovanna Elisiana, Crimi Nunzio, Crimi Claudia
Abstract excerpt
BACKGROUND: β2-adrenergic signaling promotes airway smooth muscle relaxation and limits the release of pro-inflammatory mediators by immune cells. The rs1042713 polymorphism encodes a glycine-to-arginine substitution (Arg16Gly) that enhances β2-receptor downregulation. We investigated the association of this polymorphism with the risk of severe eosinophilic asthma and its impact on the long-term effectiveness of...
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