Article
Association analysis of RGS7BP gene polymorphisms with aspirin intolerance in asthmatic patients.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology - 1 Apr 2011
Lee Eun Hee, Park Byung Lae, Park Se-Min, Lee Shin Hwa, Park Sung-Woo, Park Jong-Sook, Uh Soo-Taek, Kim Mi-Kyeong, Choi Inseon S, Cho Sang Heon, Hong Chein-Soo, Lee Jae-Young, Choi Byoung Whui, Shin Hyoung Doo, Park Choon-Sik
Abstract excerpt
BACKGROUND: Signal-regulated palmitoylation of RGS7BP(regulator of G-protein-signaling 7-binding protein) initiates the activation of G-protein-coupled receptors (GPCRs), including muscarinic receptors, which contribute to the development of asthma and its subphenotypes. OBJECTIVE: To determine the association of RGS7BP gene polymorphisms with the development of aspirin-exacerbated respiratory disease (AERD)....
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