Article
TIN2 deficiency leads to ALT-associated phenotypes and differentiation defects in embryonic stem cells.
Stem cell reports - 10 May 2022
Yin Shanshan, Zhang Fangyingnan, Lin Song, Chen Wei, Weng Kai, Liu Dan, Wang Chuanle, He Zibin, Chen Yuxi, Ma Wenbin, Huang Junjiu, Huang Yan, Songyang Zhou
Abstract excerpt
Telomere integrity is critical for embryonic development, and core telomere-binding proteins, such as TIN2, are key to maintaining telomere stability. Here, we report that homozygous Tin2S341X resulted in embryonic lethality in mice and reduced expression of Tin2 in the derived mouse embryonic stem cells (mESCs). Homozygous mutant mESCs were able to self-renew and remain undifferentiated but displayed many...
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