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Article

PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells.

Nucleic acids research - 1 Apr 2013

Chang Fiona T M, McGhie James D, Chan F Lyn, Tang Michelle C, Anderson Melissa A, Mann Jeffrey R, Andy Choo K H, Wong Lee H

Abstract excerpt

We have previously shown that α-thalassemia mental retardation X-linked (ATRX) and histone H3.3 are key regulators of telomeric chromatin in mouse embryonic stem cells. The function of ATRX and H3.3 in the maintenance of telomere chromatin integrity is further demonstrated by recent studies that show the strong association of ATRX/H3.3 mutations with alternative lengthening of telomeres in telomerase-negative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23444137
DOI: 10.1093/nar/gkt114
PMCID: PMC3632112

Genes

PML
ATRX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells.PMID 23444137Read ↗

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PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengtheningSemantic proximity Read ↗

ATRX, a guardian of chromatinSemantic proximity Read ↗

TIN2 deficiency leads to ALT-associated phenotypes and differentiation defects in embryonic stem cells.Semantic proximity Read ↗

From pathology to therapy: A comprehensive review of ATRX mutation related molecular functions and disorders.Semantic proximity Read ↗

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PML is required for telomere stability in non-neoplastic human cellsSemantic proximity Read ↗

Orphan nuclear receptors-induced ALT-associated PML bodies are targets for ALT inhibitionSemantic proximity Read ↗

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