Article

The telomeric factor TIN2 safeguards rDNA integrity and reveals Dyskeratosis Congenita as a combined telomere–rDNA disorder

2026-08-26

Abstract excerpt

<title>Abstract</title> <p>Telomeropathies and ribosomopathies share clinical features such as bone marrow failure, developmental defects and cancer predisposition, suggesting convergent pathogenic mechanisms, yet a broadly unifying molecular basis is lacking. Here we identify the telomeric shelterin component TIN2 as a key regulator of nucleolar function and rDNA stability, thereby linking these disease entities...

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Literature Corpus work: 7969ebbb-e91f-5805-9733-1acfb41d2b64
DOI: 10.21203/rs.3.rs-8807514/v1

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