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Article

TRFH domain is critical for TRF1-mediated telomere stabilization.

Cell structure and function - 1 Jan 2009

Okamoto Keiji, Shinkai Yoichi

Abstract excerpt

The telomeres are nucleoprotein complexes essential for maintaining the genomic integrity of linear chromosomes. Six telomere localizing proteins form a complex named "shelterin/telosome" to cooperatively regulate telomere length and protect chromosomal ends from DNA damage and repair responses. Mouse embryonic stem (ES) cells lacking TRF1, a shelterin component, exhibit a high-incidence of broken or lost...

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Identifiers

PMID: 19521025
DOI: 10.1247/csf.09007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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