Article
Novel hybridization- and tag-based error-corrected method for sensitive ctDNA mutation detection using ion semiconductor sequencing.
Scientific reports - 6 Apr 2022
Tjensvoll Kjersti, Lapin Morten, Gilje Bjørnar, Garresori Herish, Oltedal Satu, Forthun Rakel Brendsdal, Molven Anders, Rozenholc Yves, Nordgård Oddmund
Abstract excerpt
Circulating tumor DNA (ctDNA) analysis has emerged as a clinically useful tool for cancer diagnostics and treatment monitoring. However, ctDNA detection is complicated by low DNA concentrations and technical challenges. Here we describe our newly developed sensitive method for ctDNA detection on the Ion Torrent sequencing platform, which we call HYbridization- and Tag-based Error-Corrected sequencing (HYTEC-seq)....
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