Detection of Circulating Tumor DNA in Patients with Pancreatic Cancer Using Digital Next-Generation Sequencing.

doi:10.1016/j.jmoldx.2020.02.010

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Detection of Circulating Tumor DNA in Patients with Pancreatic Cancer Using Digital Next-Generation Sequencing.

The Journal of molecular diagnostics : JMD - 1 Jun 2020

Macgregor-Das Anne, Yu Jun, Tamura Koji, Abe Toshiya, Suenaga Masaya, Shindo Koji, Borges Michael, Koi Chiho, Kohi Shiro, Sadakari Yoshihiko, Dal Molin Marco, Almario Jose A, Ford Madeline, Chuidian Miguel, Burkhart Richard, He Jin, Hruban Ralph H, Eshleman James R, Klein Alison P, Wolfgang Christopher L, Canto Marcia I, Goggins Michael

Abstract excerpt

Circulating tumor DNA (ctDNA) measurements can be used to estimate tumor burden, but avoiding false-positive results is challenging. Herein, digital next-generation sequencing (NGS) is evaluated as a ctDNA detection method. Plasma KRAS and GNAS hotspot mutation levels were measured in 140 subjects, including 67 with pancreatic ductal adenocarcinoma and 73 healthy and disease controls. To limit chemical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromogranins

Share to Circulating Tumor DNA

Share to Codon

Share to GTP-Binding Protein alpha Subunits, Gs

Share to High-Throughput Nucleotide Sequencing

Share to Pancreatic Neoplasms

Share to Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 32205290
DOI: 10.1016/j.jmoldx.2020.02.010
PMCID: PMC7338889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of Circulating Tumor DNA in Patients with Pancreatic Cancer Using Digital Next-Generation Sequencing.PMID 32205290Read ↗

Digital next‐generation sequencing of cell‐free DNA for pancreatic cancerSemantic proximity Read ↗

Prospective Evaluation of Circulating Tumor DNA Using Next-generation Sequencing as a Biomarker During Neoadjuvant Chemotherapy in Localized Pancreatic CancerSemantic proximity Read ↗

Detection of circulating tumor DNA without a tumor-informed search using next-generation sequencing is a prognostic biomarker in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms.Semantic proximity Read ↗

Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer.Semantic proximity Read ↗

Digital PCR-based plasma cell-free DNA mutation analysis for early-stage pancreatic tumor diagnosis and surveillance.Semantic proximity Read ↗

Circulating Tumor DNA and Tissue Testing for Pancreatobiliary Tumors.Semantic proximity Read ↗

Parallel Analysis of Pre- and Postoperative Circulating Tumor DNA and Matched Tumor Tissues in Resectable Pancreatic Ductal Adenocarcinoma: A Prospective Cohort Study.Semantic proximity Read ↗

Enrichment of short mutant cell-free DNA fragments enhanced detection of pancreatic cancerSemantic proximity Read ↗

Circulating tumor DNA tracking in patients with pancreatic cancer using next-generation sequencing.Semantic proximity Read ↗

Longitudinal profiling of circulating tumour DNA for tracking tumour dynamics in pancreatic cancer.Semantic proximity Read ↗

Selective identification of somatic mutations in pancreatic cancer cells through a combination of next-generation sequencing of plasma DNA using molecular barcodes and a bioinformatic variant filter.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.