Article
Detection of Rare Mutations in CtDNA Using Next Generation Sequencing.
Journal of visualized experiments : JoVE - 24 Aug 2017
Lv Xiaoxing, Zhao Meiru, Yi Yuting, Zhang Lucheng, Guan Yanfang, Liu Tao, Yang Ling, Chen Rongrong, Ma Jianhui, Yi Xin
Abstract excerpt
The analysis of circulating tumor DNA (ctDNA) using next-generation sequencing (NGS) has become a valuable tool for the development of clinical oncology. However, the application of this method is challenging due to its low sensitivity in analyzing the trace amount of ctDNA in the blood. Furthermore, the method may generate false positive and negative results from this sequencing and subsequent analysis. To...
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