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NADPH metabolism determines the leukemogenic capacity and drug resistance of AML cells

1 Apr 2022

Abstract excerpt

The mechanism by which redox metabolism regulates the fates of acute myeloid leukemia (AML) cells remains largely unknown. Using a highly sensitive, genetically encoded fluorescent sensor of nicotinamide adenine dinucleotide phosphate (NADPH), iNap1, we find three heterogeneous subpopulations of AML cells with different cytosolic NADPH levels in an MLL-AF9-induced murine AML model. The iNap1-high AML cells have...

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PMID: 35385727
DOI: 10.1016/j.celrep.2022.110607

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