Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting MTHFD2 in acute myeloid leukemia

20 Jun 2016

Abstract excerpt

Drugs targeting metabolism have formed the backbone of therapy for some cancers. We sought to identify new such targets in acute myeloid leukemia (AML). The one-carbon folate pathway, specifically methylenetetrahydrofolate dehydrogenase-cyclohydrolase 2 (MTHFD2), emerged as a top candidate in our analyses. MTHFD2 is the most differentially expressed metabolic enzyme in cancer versus normal cells. Knockdown of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Epigenetics and DNA Methylation
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27325891
DOI: 10.1084/jem.20151574

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting MTHFD2 in acute myeloid leukemiaPMID 27325891Read ↗

More Than a Metabolic Enzyme: MTHFD2 as a Novel Target for Anticancer Therapy?Semantic proximity Read ↗

Targeting MTHFD2 disrupts mitochondrial redox homeostasis and restores venetoclax sensitivity in acute myeloid leukemiaSemantic proximity Read ↗

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based InhibitorSemantic proximity Read ↗

MTHFD2 in healthy and cancer cells: Canonical and non-canonical functionsSemantic proximity Read ↗

A Review of Small-Molecule Inhibitors of One-Carbon Enzymes: SHMT2 and MTHFD2 in the SpotlightSemantic proximity Read ↗

Imetelstat-Mediated Alterations in Fatty Acid Metabolism To Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid LeukemiaSemantic proximity Read ↗

Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemiaSemantic proximity Read ↗

Metabolism in acute myeloid leukemia: mechanistic insights and therapeutic targetsSemantic proximity Read ↗

Reductive TCA cycle catalyzed by wild-type IDH2 promotes acute myeloid leukemia and is a metabolic vulnerability for potential targeted therapy.Semantic proximity Read ↗

Intersection of Epigenetic and Metabolic Regulation of Histone Modifications in Acute Myeloid LeukemiaSemantic proximity Read ↗

Mitochondrial one-carbon enzyme MTHFD1L sustains stemness and metastatic progression in breast cancerSemantic proximity Read ↗

Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.