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Article

NPM1 mutation promotes creatine anabolism by FTO-dependent m6A demethylation to drive macrophage M2 polarization in acute myeloid leukemia.

Cancer letters - 1 Oct 2026

Wang Jun-Dan, Liao Chen-Jia, Lei Xin-Xing, Peng Zi-Zhen, Lin Zhi-Li, Liu Jia-Jun, Liu Quentin, Zhang Ling, Long Zi-Jie

Abstract excerpt

Nucleophosmin 1-mutant (NPM1MU) acute myeloid leukemia (AML) represents a distinct molecular subtype, yet the mechanisms underlying NPM1 mutation-driven malignant transformation remain incompletely understood. Here, we find prevalent copy number variations (CNVs) of N6-methyladenosine (m6A) key regulators in NPM1 wild-type (NPM1WT) AML patients, whereas such alterations are rarely detected in NPM1MU subgroup....

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Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42217563
DOI: 10.1016/j.canlet.2026.218637

Genes

FTO
NPM1
CCL2
CXCL13
GAMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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