Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia.

Nature communications - 1 Mar 2022

Erdem Ayşegül, Marin Silvia, Pereira-Martins Diego A, Cortés Roldán, Cunningham Alan, Pruis Maurien G, de Boer Bauke, van den Heuvel Fiona A J, Geugien Marjan, Wierenga Albertus T J, Brouwers-Vos Annet Z, Rego Eduardo M, Huls Gerwin, Cascante Marta, Schuringa Jan Jacob

Abstract excerpt

Acute myeloid leukemia remains difficult to treat due to strong genetic heterogeneity between and within individual patients. Here, we show that Pyruvate dehydrogenase kinase 1 (PDK1) acts as a targetable determinant of different metabolic states in acute myeloid leukemia (AML). PDK1low AMLs are OXPHOS-driven, are enriched for leukemic granulocyte-monocyte progenitor (L-GMP) signatures, and are associated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to fms-Like Tyrosine Kinase 3

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heterografts

Share to Leukemia, Myeloid, Acute

Share to Myeloid Progenitor Cells

Share to Oxidative Phosphorylation

Share to Pyruvate Dehydrogenase Acetyl-Transferring Kinase

Source

Open in PubMed Open full text

Identifiers

PMID: 35232995
DOI: 10.1038/s41467-022-28737-3
PMCID: PMC8888573

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia.PMID 35232995Read ↗

Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemiaSemantic proximity Read ↗

PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia.Semantic proximity Read ↗

Rationale for Targeting Deregulated Metabolic Pathways as a Therapeutic Strategy in Acute Myeloid LeukemiaSemantic proximity Read ↗

A metabolic synthetic lethality of phosphoinositide 3-kinase-driven cancerSemantic proximity Read ↗

Energy metabolism is co-determined by genetic variants in chronic lymphocytic leukemia and influences drug sensitivitySemantic proximity Read ↗

High PD‑L1 expression drives glycolysis via an Akt/mTOR/HIF‑1α axis in acute myeloid leukemiaSemantic proximity Read ↗

Acute Myeloid Leukaemia Drives Metabolic Changes in the Bone Marrow NicheSemantic proximity Read ↗

Profiling the Effect of Targeting Wild Isocitrate Dehydrogenase 1 (IDH1) on the Cellular Metabolome of Leukemic Cells.Semantic proximity Read ↗

Glycolytic Enzyme PKM2 Mediates Autophagic Activation to Promote Cell Survival in NPM1-Mutated LeukemiaSemantic proximity Read ↗

Advances in pathogenesis research and challenges in treatment development for acute myeloid leukemia.Semantic proximity Read ↗

Profiling The Effect of Targeting Wild Isocitrate Dehydrogenase 1 (IDH1) on the Cellular Metabolome of Leukemic CellsSemantic proximity Read ↗

Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.