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Article

The genotypes and phenotypes of missense mutations in the proline domain of the p53 protein.

Cell death and differentiation - 1 May 2022

Hoyos David, Greenbaum Benjamin, Levine Arnold J

Abstract excerpt

The p53 protein is structurally and functionally divided into five domains. The proline-rich domain is localized at amino acids 55-100. 319 missense mutations were identified solely in the proline domain from human cancers. Six hotspot mutations were identified at amino acids 72, 73, 82, 84, 89, and 98. Codon 72 contains a polymorphism that changes from proline (and African descent) to arginine (with Caucasian...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35383292
DOI: 10.1038/s41418-022-00980-7
PMCID: PMC9090814

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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