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Article

The multifunctional proline-rich domain of p53 tumor suppressor.

Biochimica et biophysica acta. Reviews on cancer - 1 Jul 2025

Zhang Yuesheng, Dutta Madhuri

Abstract excerpt

The p53 tumor suppressor is a multi-domain protein. The proline-rich domain (PRD) resides next to the transactivation domains at the N-terminus and before the DNA binding domain. The PRD has been studied extensively for nearly three decades and has been shown to be a key component for the tumor suppressor functions of p53. However, study findings have not been analyzed systematically. Herein, we undertake a...

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Identifiers

PMID: 40258446
DOI: 10.1016/j.bbcan.2025.189326
PMCID: PMC13052475

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