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Article

Engineered pH-Sensitive Protein G/IgG Interaction.

ACS chemical biology - 16 Jul 2021

Jha Ramesh K, Yankey Allison, Shabazz Kalifa, Naranjo Leslie, Shin Sang-Min, Velappan Nileena, Bradbury Andrew R M, Strauss Charlie E M

Abstract excerpt

While natural protein-protein interactions have evolved to be induced by complex stimuli, rational design of interactions that can be switched-on-demand still remain challenging in the protein design world. Here, we demonstrate that a computationally redesigned natural interface for improved binding affinity could further be mutated to adopt a pH switchable interaction. The redesigned interface of Protein G/human...

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Identifiers

PMID: 34152722
DOI: 10.1021/acschembio.0c00943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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