Article

Rational design of oxidation-resistant antibodies through local electrostatic modulation

2025-07-04

Abstract excerpt

Oxidation is a significant degradation pathway in proteins, particularly therapeutic antibodies, that can impair function, efficacy, and stability. Understanding the sequence and structural factors that drive oxidation susceptibility is critical for incorporating chemical stability into early-stage antibody design. Here, we present a machine learning classifier trained on expert-guided structural features to asses...

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Literature Corpus work: 3dab60e3-d38d-57b7-bb42-cac4b7c6c2c1
DOI: 10.1101/2025.06.29.662139

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