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Article

TGFβ selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition.

Molecular oncology - 1 Jun 2022

Tsubakihara Yutaro, Ohata Yae, Okita Yukari, Younis Shady, Eriksson Jens, Sellin Mikael E, Ren Jiang, Ten Dijke Peter, Miyazono Kohei, Hikita Atsuhiko, Imamura Takeshi, Kato Mitsuyasu, Heldin Carl-Henrik, Moustakas Aristidis

Abstract excerpt

Transforming growth factor β (TGFβ) induces epithelial-mesenchymal transition (EMT), which correlates with stemness and invasiveness. Mesenchymal-epithelial transition (MET) is induced by TGFβ withdrawal and correlates with metastatic colonization. Whether TGFβ promotes stemness and invasiveness simultaneously via EMT remains unclear. We established a breast cancer cell model expressing red fluorescent protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35348275
DOI: 10.1002/1878-0261.13215
PMCID: PMC9208077

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