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Article

Differential Contributions of Pre- and Post-EMT Tumor Cells in Breast Cancer Metastasis.

Cancer research - 15 Jan 2020

Lourenco Ana Rita, Ban Yi, Crowley Michael J, Lee Sharrell B, Ramchandani Divya, Du Wei, Elemento Olivier, George Jason T, Jolly Mohit Kumar, Levine Herbert, Sheng Jianting, Wong Stephen T, Altorki Nasser K, Gao Dingcheng

Abstract excerpt

Metastases are responsible for the majority of breast cancer-associated deaths. The contribution of epithelial-to-mesenchymal transition (EMT) in the establishment of metastases is still controversial. To obtain in vivo evidence of EMT in metastasis, we established an EMT lineage tracing (Tri-PyMT) model, in which tumor cells undergoing EMT would irreversibly switch their fluorescent marker from RFP+ to GFP+ due...

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Identifiers

PMID: 31704888
DOI: 10.1158/0008-5472.CAN-19-1427
PMCID: PMC6980649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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