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Article

Reprogramming during epithelial to mesenchymal transition under the control of TGFβ

17 Nov 2014

Abstract excerpt

Epithelial-mesenchymal transition (EMT) refers to plastic changes in epithelial tissue architecture. Breast cancer stromal cells provide secreted molecules, such as transforming growth factor β (TGFβ), that promote EMT on tumor cells to facilitate breast cancer cell invasion, stemness and metastasis. TGFβ signaling is considered to be abnormal in the context of cancer development; however, TGFβ acting on breast...

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PMID: 25482613
DOI: 10.4161/19336918.2014.983794

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