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Article

Distinct contributions of partial and full EMT to breast cancer malignancy

29 Nov 2021

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is a transient, reversible process of cell de-differentiation where cancer cells transit between various stages of an EMT continuum, including epithelial, partial EMT, and mesenchymal cell states. We have employed Tamoxifen-inducible dual recombinase lineage tracing systems combined with live imaging and 5-cell RNA sequencing to track cancer cells undergoing partial or full...

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Identifiers

PMID: 34847378
DOI: 10.1016/j.devcel.2021.11.006

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