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Article

A 3D in vitro model to explore the inter-conversion between epithelial and mesenchymal states during EMT and its reversion.

Scientific reports - 3 Jun 2016

Bidarra S J, Oliveira P, Rocha S, Saraiva D P, Oliveira C, Barrias C C

Abstract excerpt

Epithelial-to-mesenchymal transitions (EMT) are strongly implicated in cancer dissemination. Intermediate states, arising from inter-conversion between epithelial (E) and mesenchymal (M) states, are characterized by phenotypic heterogeneity combining E and M features and increased plasticity. Hybrid EMT states are highly relevant in metastatic contexts, but have been largely neglected, partially due to the lack...

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PMID: 27255191
DOI: 10.1038/srep27072
PMCID: PMC4891772

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