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Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

5 Aug 2008

Abstract excerpt

Recently, two novel concepts have emerged in cancer biology: the role of so-called "cancer stem cells" in tumor initiation, and the involvement of an epithelial-mesenchymal transition (EMT) in the metastatic dissemination of epithelial cancer cells. Using a mammary tumor progression model, we show that cells possessing both stem and tumorigenic characteristics of "cancer stem cells" can be derived from human...

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PMID: 18682804
DOI: 10.1371/journal.pone.0002888

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