TLR-2 derangements likely play a significant role in the inflammatory response and thrombosis in patients with Ph(-) classical myeloproliferative neoplasm

Abstract excerpt

<title>Abstract</title> <p>This study investigated TLRs on inflammatory pathways in <italic>Ph</italic>(-)MPNs. The results showed that TLR2 were increased in PV and MPN (PV + ET + MF), while TLR4 were only increased in MPN. TLR3, 7, and 9 were not elevated. We further cultured mdDC cells and demonstrating TLR2 elevated (TLR-E) patients secreted more cytokines than TLR2 normal (TLR-N), confirming the importance o...

Topics

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• Bone Marrow Neoplasms
• Polycythemia Vera
• Primary Myelofibrosis
• Thrombocythemia, Essential
• Toll-Like Receptor 2
• Toll-Like Receptor 4
• Toll-Like Receptor 9
• Toll-Like Receptors

Identifiers and source

Literature Corpus work

b849fe24-8225-5078-9c4f-845f84aca7b5

DOI

10.21203/rs.3.rs-3256777/v1