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Cytokine Profiling in Myeloproliferative Neoplasms: Overview on Phenotype Correlation, Outcome Prediction, and Role of Genetic Variants.

Cells - 21 Sept 2020

Masselli Elena, Pozzi Giulia, Gobbi Giuliana, Merighi Stefania, Gessi Stefania, Vitale Marco, Carubbi Cecilia

Abstract excerpt

Among hematologic malignancies, the classic Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) are considered a model of inflammation-related cancer development. In this context, the use of immune-modulating agents has recently expanded the MPN therapeutic scenario. Cytokines are key mediators of an auto-amplifying, detrimental cross-talk between the MPN clone and the tumor microenvironment...

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Cell Communication
Hematologic Neoplasms
Immunologic Factors
Megakaryocytes
Polycythemia Vera

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Primary Myelofibrosis

Thrombocythemia, Essential

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PMID: 32967342
DOI: 10.3390/cells9092136
PMCID: PMC7564952

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