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Article

CDH1 germline mutations in healthy individuals from families with the hereditary diffuse gastric cancer syndrome.

Journal of medical genetics - 1 Apr 2022

Corso Giovanni, Magnoni Francesca, Massari Giulia, Trovato Cristina Maria, De Scalzi Alessandra Margherita, Vicini Elisa, Bonanni Bernardo, Veronesi Paolo, Galimberti Viviana, Bagnardi Vincenzo

Abstract excerpt

The objective of this study was to determining the frequency of different sub-types of pathogenic CDH1 germline mutations in healthy and asymptomatic individuals from families with the hereditary diffuse gastric cancer (HDGC) syndrome. Relevant literature dating from 1998 to 2019 was systematically searched for data on CDH1 germline mutations. The collected variants were classified according to their subtype into...

Topics

Adenocarcinoma
Antigens, CD
Cadherins
Case-Control Studies
Genetic Predisposition to Disease
Genetic Testing
Germ-Line Mutation
Humans
Pedigree
Stomach Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34952833
DOI: 10.1136/jmedgenet-2021-108226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-34952833-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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