Article
Germline likely pathogenic variants in ataxia-telangiectasia-mutated gene in an Iranian family with hereditary diffuse gastric cancer without CDH1 mutation.
Journal of cancer research and therapeutics - 1 Jan 2000
Kheirollahi Majid, Saneipour Maryam, Moridnia Abbas
Abstract excerpt
BACKGROUND: Gastric cancer (GC) is the fourth common cancer in the world and the second cause of cancer-related mortality. Germline mutations in the E-cadherin gene (CDH1) are the most common cause of hereditary diffuse GC (HDGC) and explain 25%-30% of cases. In HDGC families without the pathogen...
Topics
- Adult
- Antigens, CD
- Ataxia Telangiectasia Mutated Proteins
- Cadherins
- Female
- Follow-Up Studies
- Genetic Predisposition to Disease
- Genotype
- Germ-Line Mutation
- Humans
- INDEL Mutation
- Iran
- Male
- Middle Aged
- Pedigree
- Prognosis
- Software
- Stomach Neoplasms