Article
Tumour biology: senescence in premalignant tumours.
Nature - 4 Aug 2005
Collado Manuel, Gil Jesús, Efeyan Alejo, Guerra Carmen, Schuhmacher Alberto J, Barradas Marta, Benguría Alberto, Zaballos Angel, Flores Juana M, Barbacid Mariano, Beach David, Serrano Manuel
Abstract excerpt
Oncogene-induced senescence is a cellular response that may be crucial for protection against cancer development, but its investigation has so far been restricted to cultured cells that have been manipulated to overexpress an oncogene. Here we analyse tumours initiated by an endogenous oncogene, ras, and show that senescent cells exist in premalignant tumours but not in malignant ones. Senescence is therefore a...
Topics
- Adenocarcinoma
- Alleles
- Animals
- Biomarkers, Tumor
- Cell Transformation, Neoplastic
- Cellular Senescence
- Cyclin-Dependent Kinase Inhibitor p16
- Disease Models, Animal
- Disease Progression
- Gene Expression Regulation, Neoplastic